Milan Criteria in Liver Transplantation for Hepatocellular Carcinoma

 

Number and size of hepatocellular carcinoma tumors in the liver
		One tumor ≤5 cm in diameter (0 points)
		Up to three tumors, each ≤3 cm in diameter (0 points)
		More than three tumors (1 point)
		Any tumor >5 cm in diameter (1 point)
Tumor invasion of lymph nodes
		No (0 points)
		Yes (1 point)
Tumor invasion of blood vessels
		No (0 points)
		Yes (1 point)

 

Total Criteria Point Count:
 

 

Milan Criteria Interpretation

 

0 points:	Transplantation may be considered
1 to 3 points:	Transplantation may be futile

 

 

References

1. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996 Mar 14;334(11):693-9. PubMed ID: 8594428
2. Martin P, DiMartini A, Feng S, et al. Evaluation for liver transplantation in adults: 2013 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation. Hepatology. 2014 Mar;59(3):1144-65. PubMed ID: 24716201